Target:PC-PLD2
Fields:Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Ras signaling pathway;cAMP signaling pathway;Sphingolipid signaling pathway;Phospholipase D signaling pathway;Endocytosis;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;GnRH signaling pathway;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Chemical carcinogenesis - reactive oxygen species;Pancreatic cancer;Choline metabolism in cancer
Gene Name:PLD2
Protein Name:Phospholipase D2
Human Gene Id:5338
Human Swiss Prot No:O14939
Mouse Gene Id:18806
Mouse Swiss Prot No:P97813
Rat Gene Id:25097
Rat Swiss Prot No:P70498
Immunogen:Synthesized peptide derived from PC-PLD2 . at AA range: 110-190
Specificity:PC-PLD2 Polyclonal Antibody detects endogenous levels of PC-PLD2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PLD2;Phospholipase D2;PLD 2;hPLD2;Choline phosphatase 2;PLD1C;Phosphatidylcholine-hydrolyzing phospholipase D2
Observed Band(KD):106kD
Background: The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],
Function:catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).,function:May have a role in signal-induced cytoskeletal regulation and/or endocytosis.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with EGFR (By similarity). Interacts with PIP5K1A.,tissue specificity:Ubiquitous.,
Subcellular Location:Cell membrane ; Lipid-anchor .
Expression:Ubiquitous.