Target：PGE synthase
Fields：Arachidonic acid metabolism;Metabolic pathways
Gene Name：PTGES
Protein Name：Prostaglandin E synthase
Human Gene Id：9536
Human Swiss Prot No：O14684
Mouse Gene Id：64292
Mouse Swiss Prot No：Q9JM51
Immunogen：The antiserum was produced against synthesized peptide derived from human PGE synthase. AA range:30-79
Specificity：PGE synthase Polyclonal Antibody detects endogenous levels of PGE synthase protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PTGES;MGST1L1;MPGES1;PGES;PIG12;Prostaglandin E synthase;Microsomal glutathione S-transferase 1-like 1;MGST1-L1;Microsomal prostaglandin E synthase 1;MPGES-1;p53-induced gene 12 protein
Observed Band(KD)：17kD
Background：prostaglandin E synthase(PTGES) Homo sapiens The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008],
Function：catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.,induction:By TP53/p53.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,
Subcellular Location：Membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. .
Expression： Breast,Colon cancer,Pancreas,
