Target：PGD

Fields：Pentose phosphate pathway;Glutathione metabolism;Metabolic pathways;Carbon metabolism

Gene Name：PGD

Protein Name：6-phosphogluconate dehydrogenase decarboxylating

Human Gene Id：5226

Human Swiss Prot No：P52209

Mouse Gene Id：110208

Mouse Swiss Prot No：Q9DCD0

Rat Gene Id：1.0036e+008

Rat Swiss Prot No：P85968

Immunogen：The antiserum was produced against synthesized peptide derived from human PGD. AA range:71-120

Specificity：PGD Polyclonal Antibody detects endogenous levels of PGD protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PGD;PGDH;6-phosphogluconate dehydrogenase; decarboxylating

Observed Band(KD)：40kD

Background： 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Function：catalytic activity:6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.,similarity:Belongs to the 6-phosphogluconate dehydrogenase family.,subunit:Homodimer.,

Subcellular Location：Cytoplasm .

Expression： Heart,Lung,