Target：PFK-2 liv/tes

Fields：Fructose and mannose metabolism;Metabolic pathways;AMPK signaling pathway;Glucagon signaling pathway

Gene Name：PFKFB1/PFKFB4

Protein Name：6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1/4

Human Gene Id：5207/5210

Human Swiss Prot No：P16118/Q16877

Mouse Gene Id：18639/270198

Rat Gene Id：24638/54283

Rat Swiss Prot No：P07953/P25114

Immunogen：The antiserum was produced against synthesized peptide derived from human PFKFB1/4. AA range:331-380

Specificity：PFK-2 liv/tes Polyclonal Antibody detects endogenous levels of PFK-2 liv/tes protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PFKFB1;F6PK;PFRX;6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 1;6PF-2-K/Fru-2,6-P2ase 1;PFK/FBPase 1;6PF-2-K/Fru-2,6-P2ase liver isozyme;PFKFB4;6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4;6PF-2-K/Fru-2,6-P2ase 4;

Observed Band(KD)：54kD

Background： This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],

Function：catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in inhibition of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Liver.,

Subcellular Location：cytosol,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex,

Expression：Liver.