Target：PinX1

Gene Name：PINX1

Protein Name：PIN2/TERF1-interacting telomerase inhibitor 1

Human Gene Id：54984

Human Swiss Prot No：Q96BK5

Mouse Swiss Prot No：Q9CZX5

Immunogen：The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170

Specificity：PinX1 Polyclonal Antibody detects endogenous levels of PinX1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PINX1;LPTL;LPTS;PIN2/TERF1-interacting telomerase inhibitor 1;Liver-related putative tumor suppressor;Pin2-interacting protein X1;Protein 67-11-3;TRF1-interacting protein 1

Molecular Weight(Da)：37kD

Background：domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.,function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.,similarity:Belongs to the PINX1 family.,similarity:Contains 1 G-patch domain.,subcellular location:In nucleoli and at telomere speckles.,subunit:Binds to MCRS1, TERT and TERF1.,tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,

Function：domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.,function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.,similarity:Belongs to the PINX1 family.,similarity:Contains 1 G-patch domain.,subcellular location:In nucleoli and at telomere speckles.,subunit:Binds to MCRS1, TERT and TERF1.,tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,

Subcellular Location：Nucleus . Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Expression：Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.