Target：RGS5

Gene Name：RGS5

Protein Name：Regulator of G-protein signaling 5

Human Gene Id：8490

Human Swiss Prot No：O15539

Mouse Gene Id：19737

Mouse Swiss Prot No：O08850

Rat Gene Id：54294

Rat Swiss Prot No：P49800

Immunogen：The antiserum was produced against synthesized peptide derived from human RGS5. AA range:89-138

Specificity：RGS5 Polyclonal Antibody detects endogenous levels of RGS5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RGS5;Regulator of G-protein signaling 5;RGS5

Observed Band(KD)：20kD

Background： This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011],

Function：function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.,similarity:Contains 1 RGS domain.,

Subcellular Location：[Isoform 1]: Cytoplasm . Membrane .; [Isoform 2]: Cytoplasm .

Expression： Aorta,Brain,Human cervix,Liver,Neuroblastoma,Normal aorta,