Target:AASD-PPT
Fields:Pantothenate and CoA biosynthesis;Metabolic pathways
Gene Name:AASDHPPT
Protein Name:L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Human Gene Id:60496
Human Swiss Prot No:Q9NRN7
Mouse Gene Id:67618
Mouse Swiss Prot No:Q9CQF6
Rat Gene Id:300328
Rat Swiss Prot No:B2RYJ4
Immunogen:The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60
Specificity:AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:AASDHPPT;CGI-80;HAH-P;HSPC223;x0005;L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase;4'-phosphopantetheinyl transferase;Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase;AASD-PPT;
Observed Band(KD):36kD
Background: The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],
Function:catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.,
Subcellular Location:Cytoplasm, cytosol .
Expression:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.