Target：PIG-X
Fields：Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways
Gene Name：PIGX
Protein Name：Phosphatidylinositol-glycan biosynthesis class X protein
Human Gene Id：54965
Human Swiss Prot No：Q8TBF5
Mouse Swiss Prot No：Q99LV7
Immunogen：The antiserum was produced against synthesized peptide derived from human PIGX. AA range:183-232
Specificity：PIG-X Polyclonal Antibody detects endogenous levels of PIG-X protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PIGX;Phosphatidylinositol-glycan biosynthesis class X protein;PIG-X
Observed Band(KD)：26kD
Background： This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Function：function:Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,PTM:N-glycosylated.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the PIGX family.,subunit:Interacts with PIGM.,
Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Expression： Brain,
