Target：pHyde

Fields：p53 signaling pathway;Ferroptosis

Gene Name：STEAP3

Protein Name：Metalloreductase STEAP3

Human Gene Id：55240

Human Swiss Prot No：Q658P3

Mouse Gene Id：68428

Mouse Swiss Prot No：Q8CI59

Rat Gene Id：170824

Rat Swiss Prot No：Q5RKL5

Immunogen：The antiserum was produced against synthesized peptide derived from human STEA3. AA range:421-470

Specificity：pHyde Polyclonal Antibody detects endogenous levels of pHyde protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：STEAP3;TSAP6;Metalloreductase STEAP3;Dudulin-2;Six-transmembrane epithelial antigen of prostate 3;Tumor suppressor-activated pathway protein 6;hTSAP6;pHyde;hpHyde

Observed Band(KD)：54kD

Background：STEAP3 metalloreductase(STEAP3) Homo sapiens This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Function：caution:Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).,cofactor:FAD.,function:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.,induction:By p53/TP53.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,subcellular location:Localizes to vesicular-like structures at the plasma membrane and around the nucleus.,su

Subcellular Location：Endosome membrane ; Multi-pass membrane protein . Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Expression：Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.