Target：PHKG1

Fields：Calcium signaling pathway;Insulin signaling pathway;Glucagon signaling pathway

Gene Name：PHKG1

Protein Name：Phosphorylase b kinase gamma catalytic chain skeletal muscle isoform

Human Gene Id：5260

Human Swiss Prot No：Q16816

Mouse Swiss Prot No：P07934

Immunogen：The antiserum was produced against synthesized peptide derived from human PHKG1. AA range:241-290

Specificity：PHKG1 Polyclonal Antibody detects endogenous levels of PHKG1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PHKG1;PHKG;Phosphorylase b kinase gamma catalytic chain; skeletal muscle isoform;Phosphorylase kinase subunit gamma-1

Observed Band(KD)：45kD

Background： This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],

Function：catalytic activity:2 ATP + phosphorylase b = 2 ADP + phosphorylase a.,domain:The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains.,function:Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin.,

Subcellular Location：cytosol,phosphorylase kinase complex,

Expression： PCR rescued clones,Salivary gland,Skeletal muscle,