Target：PSMD11

Fields：Proteasome;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Huntington disease;Spinocerebellar ataxia;Prion disease;Pathways of neurodegeneration - multiple diseases;Epstein-Barr virus infection

Gene Name：PSMD11

Protein Name：26S proteasome non-ATPase regulatory subunit 11

Human Gene Id：5717

Human Swiss Prot No：O00231

Mouse Gene Id：69077

Mouse Swiss Prot No：Q8BG32

Immunogen：The antiserum was produced against synthesized peptide derived from human PSMD11. AA range:271-320

Specificity：PSMD11 Polyclonal Antibody detects endogenous levels of PSMD11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PSMD11;26S proteasome non-ATPase regulatory subunit 11;26S proteasome regulatory subunit RPN6;26S proteasome regulatory subunit S9;26S proteasome regulatory subunit p44.5

Observed Band(KD)：42kD

Background： The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq,

Function：function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit S9 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,

Subcellular Location：Nucleus . Cytoplasm, cytosol .

Expression：Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.