Target：PP2Cκ

Gene Name：PPM1K

Protein Name：Protein phosphatase 1K mitochondrial

Human Gene Id：152926

Human Swiss Prot No：Q8N3J5

Mouse Swiss Prot No：Q8BXN7

Immunogen：The antiserum was produced against synthesized peptide derived from human PPM1K. AA range:205-254

Specificity：PP2Cκ Polyclonal Antibody detects endogenous levels of PP2Cκ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPM1K;PP2CM;Protein phosphatase 1K; mitochondrial;PP2C domain-containing protein phosphatase 1K;PP2C-like mitochondrial protein;PP2C-type mitochondrial phosphoprotein phosphatase;PTMP;Protein phosphatase 2C isoform kappa;PP2C-kappa

Observed Band(KD)：45kD

Background： This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012],

Function：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,

Subcellular Location：Mitochondrion matrix .

Expression： Amygdala,Cerebellum,Lymph node,Pancreas,Testis,