Target：PP2Cε

Gene Name：PPM1L

Protein Name：Protein phosphatase 1L

Human Gene Id：151742

Human Swiss Prot No：Q5SGD2

Mouse Gene Id：242083

Mouse Swiss Prot No：Q8BHN0

Immunogen：The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168

Specificity：PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPM1L;PP2CE;Protein phosphatase 1L;Protein phosphatase 1-like;Protein phosphatase 2C isoform epsilon;PP2C-epsilon

Observed Band(KD)：42kD

Background： The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Function：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.,tissue specificity:Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.