Target:RGS19
Gene Name:RGS19 GAIP GNAI3IP
Protein Name:Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
Human Gene Id:10287
Human Swiss Prot No:P49795
Mouse Swiss Prot No:Q9CX84
Rat Swiss Prot No:O70521
Immunogen:Synthesized peptide derived from human protein . at AA range: 90-170
Specificity:RGS19 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):23kD
Background: G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008],
Function:function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:Phosphorylated, mainly on serine residues.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIPC PDZ domain.,tissue specificity:Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.,
Subcellular Location:Membrane; Lipid-anchor.
Expression:Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.