Target：RGS17

Gene Name：RGS17

Protein Name：Regulator of G-protein signaling 17 (RGS17)

Human Gene Id：26575

Human Swiss Prot No：Q9UGC6

Mouse Swiss Prot No：Q9QZB0

Immunogen：Synthesized peptide derived from human protein . at AA range: 70-150

Specificity：RGS17 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：23kD

Background： This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008],

Function：function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:N- and O-glycosylated in synapsomal membranes.,PTM:Serine phosphorylated in synapsomal membranes.,PTM:Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.,similarity:Contains 1 RGS domain.,subcellular location:Shuttles between the cytoplasm/cell membrane and

Subcellular Location：Membrane . Cell junction, synapse, synaptosome . Nucleus . Cytoplasm .

Expression：Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.