Target:RGS16
Gene Name:RGS16
Protein Name:Regulator of G-protein signaling 16
Human Gene Id:6004
Human Swiss Prot No:O15492
Mouse Gene Id:19734
Mouse Swiss Prot No:P97428
Rat Swiss Prot No:P56700
Immunogen:The antiserum was produced against synthesized peptide derived from human RGS16. AA range:141-190
Specificity:RGS16 Polyclonal Antibody detects endogenous levels of RGS16 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:RGS16;RGSR;Regulator of G-protein signaling 16;RGS16;A28-RGS14P;Retinal-specific RGS;RGS-r;hRGS-r;Retinally abundant regulator of G-protein signaling
Molecular Weight(Da):23kD
Background: The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008],
Function:function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.,PTM:Palmitoylated on Cys-2 and/or Cys-12.,PTM:Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.,similarity:Contains 1 RGS domain.,tissue specificity:Abundantly expressed in retina with lower levels of expression in most other tissues.,
Subcellular Location:Membrane ; Lipid-anchor .
Expression:Abundantly expressed in retina with lower levels of expression in most other tissues.