Target：RGS12

Gene Name：RGS12

Protein Name：Regulator of G-protein signaling 12

Human Gene Id：6002

Human Swiss Prot No：O14924

Mouse Gene Id：71729

Mouse Swiss Prot No：Q8CGE9

Rat Gene Id：54292

Rat Swiss Prot No：O08774

Immunogen：The antiserum was produced against synthesized peptide derived from human RGS12. AA range:141-190

Specificity：RGS12 Polyclonal Antibody detects endogenous levels of RGS12 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RGS12;Regulator of G-protein signaling 12;RGS12

Observed Band(KD)：160kD

Background： This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008],

Function：function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 GoLoco domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 1 RGS domain.,similarity:Contains 2 RBD (Ras-binding) domains.,tissue specificity:Isoform 3 is brain specific.,

Subcellular Location：Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .; [Isoform 5]: Nucleus matrix . Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. .

Expression：Isoform 3 is brain specific.