Target：PROF2

Fields：Rap1 signaling pathway;Regulation of actin cytoskeleton;Amyotrophic lateral sclerosis;Shigellosis;Salmonella infection

Gene Name：PFN2

Protein Name：Profilin-2 (Profilin II)

Human Gene Id：5217

Human Swiss Prot No：P35080

Mouse Swiss Prot No：Q9JJV2

Rat Swiss Prot No：Q9EPC6

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PROF2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：15kD

Background： The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008],

Function：function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.,tissue specificity:Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.,

Subcellular Location：Cytoplasm, cytoskeleton.

Expression：Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.