Target：Rab 1B

Fields：Legionellosis

Gene Name：RAB1B

Protein Name：Ras-related protein Rab-1B

Human Gene Id：81876

Human Swiss Prot No：Q9H0U4

Mouse Gene Id：76308

Mouse Swiss Prot No：Q9D1G1

Rat Swiss Prot No：P10536

Immunogen：Synthesized peptide derived from Rab 1B . at AA range: 50-130

Specificity：Rab 1B Polyclonal Antibody detects endogenous levels of Rab 1B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RAB1B;Ras-related protein Rab-1B

Observed Band(KD)：22kD

Background： Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009],

Function：function:Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.,miscellaneous:Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.,PTM:Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.,subunit:Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.,

Subcellular Location：Cytoplasm . Membrane ; Lipid-anchor ; Cytoplasmic side . Preautophagosomal structure membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, perinuclear region . Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). .

Expression： B-cell lymphoma,Brain,Muscle,Pancreas,