Target：PURA

Gene Name：PURA PUR1

Protein Name：Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)

Human Gene Id：5813

Human Swiss Prot No：Q00577

Mouse Swiss Prot No：P42669

Rat Swiss Prot No：P86252

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PURA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：35kD

Background： This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008],

Function：function:This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.,similarity:Belongs to the PUR DNA-binding protein family.,subunit:Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1.,

Subcellular Location：Nucleus.

Expression： Brain,Epithelium,Fetal liver,PCR rescued clones,