Target：RASSF6

Fields：Hippo signaling pathway;Hippo signaling pathway - multiple species

Gene Name：RASSF6

Protein Name：Ras association domain-containing protein 6

Human Gene Id：166824

Human Swiss Prot No：Q6ZTQ3

Mouse Swiss Prot No：Q80UQ2

Immunogen：The antiserum was produced against synthesized peptide derived from human RASSF6. AA range:129-178

Specificity：RASSF6 Polyclonal Antibody detects endogenous levels of RASSF6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RASSF6;Ras association domain-containing protein 6

Observed Band(KD)：45kD

Background： This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012],

Function：function:May act as a Ras effector protein.,sequence caution:Translated as Gln.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,

Expression：Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.