Target:Rabphilin 3A
Gene Name:RPH3A
Protein Name:Rabphilin-3A
Human Gene Id:22895
Human Swiss Prot No:Q9Y2J0
Mouse Gene Id:19894
Mouse Swiss Prot No:P47708
Rat Gene Id:171039
Rat Swiss Prot No:P47709
Immunogen:The antiserum was produced against synthesized peptide derived from human Rabphilin 3A. AA range:203-252
Specificity:Rabphilin-3A Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:RPH3A;KIAA0985;Rabphilin-3A;Exophilin-1
Observed Band(KD):75kD
Background: Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).[supplied by OMIM, Jul 2008],
Function:function:Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains.,
Subcellular Location:Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane . Membrane ; Peripheral membrane protein .
Expression: Brain,Lung,