Target：RAGE

Fields：Neutrophil extracellular trap formation;AGE-RAGE signaling pathway in diabetic complications;Alzheimer disease;Pathways of neurodegeneration - multiple diseases;Diabetic cardiomyopathy;Lipid and atherosclerosis

Gene Name：AGER

Protein Name：Advanced glycosylation end product-specific receptor

Human Gene Id：177

Human Swiss Prot No：Q15109

Mouse Swiss Prot No：Q62151

Immunogen：The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182

Specificity：RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AGER;RAGE;Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products

Observed Band(KD)：37kD

Background： The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011],

Function：function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells.,

Subcellular Location：[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .

Expression：Endothelial cells.