Target：TBL2

Gene Name：TBL2

Protein Name：Transducin beta-like protein 2

Human Gene Id：26608

Human Swiss Prot No：Q9Y4P3

Mouse Swiss Prot No：Q9R099

Immunogen：The antiserum was produced against synthesized peptide derived from human TBL2. AA range:381-430

Specificity：TBL2 Polyclonal Antibody detects endogenous levels of TBL2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TBL2;WBSCR13;Transducin beta-like protein 2;WS beta-transducin repeats protein;WS-betaTRP;Williams-Beuren syndrome chromosomal region 13 protein

Observed Band(KD)：50kD

Background： This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008],

Function：disease:Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 7 WD repeats.,

Subcellular Location：endoplasmic reticulum,integral component of endoplasmic reticulum membrane,

Expression： Kidney,Testis,Whole embryo,