Target：THNS2

Gene Name：THNSL2

Protein Name：Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT)

Human Gene Id：55258

Human Swiss Prot No：Q86YJ6

Mouse Swiss Prot No：Q80W22

Rat Swiss Prot No：Q5M7T9

Immunogen：Synthesized peptide derived from human protein . at AA range: 91-140

Specificity：THNS2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：53kD

Background： This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],

Function：cofactor:Pyridoxal phosphate.,function:Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.,similarity:Belongs to the serine/threonine dehydratase family.,

Subcellular Location：[Isoform SOFAT]: Secreted. Secreted by activated T-cells via a calcineurin-independent pathway.

Expression： Brain,Colon,Ovarian carcinoma,Skin,Tongue,