Target：TBC1D3A/B/C

Gene Name：TBC1D3

Protein Name：TBC1 domain family member 3

Human Gene Id：414059/727735/84218/643947/414060/653380/654341/729873

Human Swiss Prot No：Q8IZP1/A6NDS4/Q6IPX1

Immunogen：The antiserum was produced against synthesized peptide derived from human TBC1D3. AA range:481-530

Specificity：TBC1D3A/B/C Polyclonal Antibody detects endogenous levels of TBC1D3A/B/C protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TBC1D3;PRC17;TBC1D3A;TBC1 domain family member 3;Prostate cancer gene 17 protein;Protein TRE17-alpha;Rab GTPase-activating protein PRC17;TBC1D3B;TBC1D3I;TBC1 domain family member 3B;TBC1D3C;TBC1D3D;TBC1 domain family member 3C

Observed Band(KD)：62kD

Background： This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],

Function：disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,

Subcellular Location：Cell membrane ; Lipid-anchor . Associated with lipid rafts.

Expression：Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.