Target：TFIIA-α

Fields：Basal transcription factors;Viral carcinogenesis

Gene Name：GTF2A1

Protein Name：Transcription initiation factor IIA subunit 1

Human Gene Id：2957

Human Swiss Prot No：P52655

Mouse Gene Id：83602

Mouse Swiss Prot No：Q99PM3

Rat Gene Id：83830

Rat Swiss Prot No：O08949

Immunogen：The antiserum was produced against synthesized peptide derived from human TF2A1. AA range:281-330

Specificity：TFIIA-α Polyclonal Antibody detects endogenous levels of TFIIA-α protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GTF2A1;TF2A1;Transcription initiation factor IIA subunit 1;General transcription factor IIA subunit 1;TFIIAL;Transcription initiation factor TFIIA 42 kDa subunit;TFIIA-42

Observed Band(KD)：42kD

Background： Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010],

Function：function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.,PTM:The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteosomal degradation.,similarity:Belongs to the TFIIA subunit 1 family.,subunit:TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.,

Subcellular Location：Nucleus.

Expression： Epithelium,