Target:TMEM16A
Gene Name:ANO1
Protein Name:Anoctamin-1
Human Gene Id:55107
Human Swiss Prot No:Q5XXA6
Mouse Swiss Prot No:Q8BHY3
Immunogen:The antiserum was produced against synthesized peptide derived from human TM16A. AA range:921-970
Specificity:TMEM16A Polyclonal Antibody detects endogenous levels of TMEM16A protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:ANO1;DOG1;ORAOV2;TAOS2;TMEM16A;Anoctamin-1;Discovered on gastrointestinal stromal tumors protein 1;Oral cancer overexpressed protein 2;Transmembrane protein 16A;Tumor-amplified and overexpressed sequence 2
Molecular Weight(Da):114kD
Background:domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,
Function:domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,
Subcellular Location:Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. .
Expression:Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.