Target:TM4SF1
Gene Name:TM4SF1
Protein Name:Transmembrane 4 L6 family member 1
Human Gene Id:4071
Human Swiss Prot No:P30408
Mouse Gene Id:17112
Mouse Swiss Prot No:Q64302
Immunogen:The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50
Specificity:TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TM4SF1;M3S1;TAAL6;Transmembrane 4 L6 family member 1;Membrane component chromosome 3 surface marker 1;Tumor-associated antigen L6
Molecular Weight(Da):22kD
Background: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],
Function:similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.,
Subcellular Location:Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). .
Expression:Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.