Target：TIMAP

Gene Name：PPP1R16B

Protein Name：Protein phosphatase 1 regulatory inhibitor subunit 16B

Human Gene Id：26051

Human Swiss Prot No：Q96T49

Mouse Gene Id：228852

Mouse Swiss Prot No：Q8VHQ3

Immunogen：The antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413

Specificity：TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPP1R16B;ANKRD4;KIAA0823;Protein phosphatase 1 regulatory inhibitor subunit 16B;Ankyrin repeat domain-containing protein 4;CAAX box protein TIMAP;TGF-beta-inhibited membrane-associated protein;hTIMAP

Observed Band(KD)：64kD

Background： The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],

Function：function:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.,

Subcellular Location：Cell membrane . Cell membrane ; Lipid-anchor . Nucleus . Cell projection . Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). .

Expression： Brain,