Target：TUT4
Gene Name：ZCCHC11 KIAA0191 TUT4
Protein Name：Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)
Human Gene Id：23318
Human Swiss Prot No：Q5TAX3
Mouse Swiss Prot No：B2RX14
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：TUT4 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：180kD
Background： ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011],
Function：RNA processing, RNA catabolic process, macromolecule catabolic process, response to organic substance, miRNA metabolic process, miRNA catabolic process, negative regulation of macromolecule metabolic process,posttranscriptional regulation of gene expression, negative regulation of gene expression, posttranscriptional gene silencing, gene silencing, stem cell maintenance, gene silencing by RNA, dsRNA fragmentation, pre-microRNA processing, RNA 3'-end processing, ncRNA processing, ncRNA metabolic process, ncRNA catabolic process,posttranscriptional gene silencing by RNA, gene silencing by miRNA, gene silencing by miRNA, production of miRNAs,regulation of gene expression, epigenetic, response to dsRNA, cellular macromolecule catabolic process, negative regulation of cell differentiation, stem cell differentiation, stem cell development,
Subcellular Location：Nucleus . Cytoplasm . Cytoplasm, Cytoplasmic ribonucleoprotein granule . Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855). Co-enriched in cytoplasmic foci with MOV10 (PubMed:30122351). .
