Target：TULA

Gene Name：UBASH3A

Protein Name：Ubiquitin-associated and SH3 domain-containing protein A

Human Gene Id：53347

Human Swiss Prot No：P57075

Mouse Swiss Prot No：Q3V3E1

Immunogen：The antiserum was produced against synthesized peptide derived from human UBASH3A. AA range:311-360

Specificity：TULA Polyclonal Antibody detects endogenous levels of TULA protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UBASH3A;STS2;Ubiquitin-associated and SH3 domain-containing protein A;Cbl-interacting protein 4;CLIP4;Suppressor of T-cell receptor signaling 2;STS-2;T-cell ubiquitin ligand 1;TULA-1

Observed Band(KD)：75kD

Background： This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Function：function:Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UBA domain.,subunit:Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.,tissue specificity:Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.,

Subcellular Location：Cytoplasm. Nucleus.

Expression：Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.