Target：TudorSN

Fields：Viral carcinogenesis

Gene Name：SND1

Protein Name：Staphylococcal nuclease domain-containing protein 1

Human Gene Id：27044

Human Swiss Prot No：Q7KZF4

Mouse Gene Id：56463

Mouse Swiss Prot No：Q78PY7

Rat Gene Id：64635

Rat Swiss Prot No：Q66X93

Immunogen：Synthesized peptide derived from the Internal region of human TudorSN.

Specificity：TudorSN Polyclonal Antibody detects endogenous levels of TudorSN protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SND1;TDRD11;Staphylococcal nuclease domain-containing protein 1;100 kDa coactivator;EBNA2 coactivator p100;Tudor domain-containing protein 11;p100 co-activator

Observed Band(KD)：101kD

Background： This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],

Function：function:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed.,

Subcellular Location：Cytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Expression：Ubiquitously expressed.