Target：TTF-I

Fields：Thyroid hormone synthesis

Gene Name：TTF1

Protein Name：Transcription termination factor 1

Human Gene Id：7270

Human Swiss Prot No：Q15361

Mouse Swiss Prot No：Q62187

Immunogen：The antiserum was produced against synthesized peptide derived from human TTF1. AA range:10-59

Specificity：TTF-I Polyclonal Antibody detects endogenous levels of TTF-I protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TTF1;Transcription termination factor 1;TTF-1;RNA polymerase I termination factor;Transcription termination factor I;TTF-I

Molecular Weight(Da)：103kD

Background： This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011],

Function：domain:The N-terminal region inhibits DNA-binding via its interaction with the C-terminal region.,function:Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with TIP5 recovers DNA-binding activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 Myb-like domains.,subunit:Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragmen

Subcellular Location：Nucleus. Nucleus, nucleolus .

Expression： Epithelium,Uterus,