Target：TTF2

Fields：Thyroid hormone synthesis

Gene Name：TTF2

Protein Name：Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2)

Human Gene Id：8458

Human Swiss Prot No：Q9UNY4

Mouse Swiss Prot No：Q5NC05

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TTF2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：127kD

Background： This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008],

Function：function:DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.,subunit:Interacts with CDC5L. Part of the spliceosome.,

Subcellular Location：Cytoplasm . Nucleus . Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Expression： Aorta endothelial cell,Brain,Epithelium,