Target：TSSK 4

Gene Name：TSSK4

Protein Name：Testis-specific serine/threonine-protein kinase 4

Human Gene Id：283629

Human Swiss Prot No：Q6SA08

Mouse Gene Id：71099

Mouse Swiss Prot No：Q9D411

Immunogen：The antiserum was produced against synthesized peptide derived from human TSSK4. AA range:211-260

Specificity：TSSK 4 Polyclonal Antibody detects endogenous levels of TSSK 4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TSSK4;C14orf20;STK22E;TSSK5;Testis-specific serine/threonine-protein kinase 4;TSK-4;TSSK-4;Testis-specific kinase 4;Serine/threonine-protein kinase 22E

Observed Band(KD)：40kD

Background： This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-197, potentially by autophosphorylation.,function:May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.,PTM:Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed only in the testis.,

Subcellular Location：Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . In spermatozoa, present in the sperm head and in the flagellum. .

Expression：Expressed only in the testis.