Target：USP44

Gene Name：USP44

Protein Name：Ubiquitin carboxyl-terminal hydrolase 44

Human Gene Id：84101

Human Swiss Prot No：Q9H0E7

Mouse Swiss Prot No：Q8C2S0

Immunogen：The antiserum was produced against synthesized peptide derived from human USP44. AA range:211-260

Specificity：USP44 Polyclonal Antibody detects endogenous levels of USP44 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：USP44;Ubiquitin carboxyl-terminal hydrolase 44;Deubiquitinating enzyme 44;Ubiquitin thioesterase 44;Ubiquitin-specific-processing protease 44

Observed Band(KD)：81kD

Background： Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008],

Function：catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Expressed in testis.,

Subcellular Location：Nucleus . Peaks in interphase, with relatively low levels maintained throughout mitosis. .

Expression：Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.