Target：USP30

Fields：Mitophagy - animal

Gene Name：USP30

Protein Name：Ubiquitin carboxyl-terminal hydrolase 30

Human Gene Id：84749

Human Swiss Prot No：Q70CQ3

Mouse Gene Id：100756

Mouse Swiss Prot No：Q3UN04

Immunogen：The antiserum was produced against synthesized peptide derived from human USP30. AA range:31-80

Specificity：USP30 Polyclonal Antibody detects endogenous levels of USP30 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：USP30;Ubiquitin carboxyl-terminal hydrolase 30;Deubiquitinating enzyme 30;Ubiquitin thioesterase 30;Ubiquitin-specific-processing protease 30;Ub-specific protease 30

Observed Band(KD)：60kd,unspecial bands( 65kd,105kd,130kd)in Hela and HCT116 cell.

Background： USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008],

Function：catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:May participate in the maintenance of mitochondrial morphology.,similarity:Belongs to the peptidase C19 family.,tissue specificity:Expressed in skeletal muscle, pancreas, liver and kidney.,

Subcellular Location：Mitochondrion outer membrane .

Expression：Expressed in skeletal muscle, pancreas, liver and kidney.