Target：UBE2G1

Fields：Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson disease;Pathways of neurodegeneration - multiple diseases

Gene Name：UBE2G1

Protein Name：Ubiquitin-conjugating enzyme E2 G1

Human Gene Id：7326

Human Swiss Prot No：P62253

Mouse Gene Id：67128

Mouse Swiss Prot No：P62254

Rat Gene Id：64631

Rat Swiss Prot No：P62255

Immunogen：Synthesized peptide derived from the Internal region of human UBE2G1.

Specificity：UBE2G1 Polyclonal Antibody detects endogenous levels of UBE2G1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UBE2G1;UBE2G;Ubiquitin-conjugating enzyme E2 G1;E217K;UBC7;Ubiquitin carrier protein G1;Ubiquitin-protein ligase G1

Molecular Weight(Da)：20kD

Background： The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,tissue specificity:Widely expressed, mainly in skeletal muscle.,

Subcellular Location：cytoplasm,extracellular exosome,

Expression：Widely expressed, mainly in skeletal muscle.