Target：UBE2D2

Fields：Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Shigellosis

Gene Name：UBE2D2

Protein Name：Ubiquitin-conjugating enzyme E2 D2

Human Gene Id：7322

Human Swiss Prot No：P62837

Mouse Gene Id：56550

Mouse Swiss Prot No：P62838

Rat Gene Id：641452

Rat Swiss Prot No：P62839

Immunogen：The antiserum was produced against synthesized peptide derived from human UBE2D2. AA range:98-147

Specificity：UBE2D2 Polyclonal Antibody detects endogenous levels of UBE2D2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UBE2D2;UBC4;UBC5B;UBCH4;UBCH5B;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin carrier protein D2;Ubiquitin-conjugating enzyme E2(17)KB 2;Ubiquitin-conjugating enzyme E2-17 kDa 2;Ubiquitin-protein ligase D2

Observed Band(KD)：17kD

Background： Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],

Function：catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2.,

Subcellular Location：ubiquitin ligase complex,nucleoplasm,cytosol,protein complex,extracellular exosome,

Expression： Brain,Cajal-Retzius cell,Testis,