Target:TRP2
Fields:Tyrosine metabolism;Metabolic pathways;Melanogenesis
Gene Name:DCT
Protein Name:L-dopachrome tautomerase
Human Gene Id:1638
Human Swiss Prot No:P40126
Mouse Gene Id:13190
Mouse Swiss Prot No:P29812
Immunogen:The antiserum was produced against synthesized peptide derived from human DCT. AA range:51-100
Specificity:TRP2 Polyclonal Antibody detects endogenous levels of TRP2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:DCT;TYRP2;L-dopachrome tautomerase;DCT;DT;L-dopachrome Delta-isomerase;Tyrosinase-related protein 2;TRP-2;TRP2
Observed Band(KD):60kD
Background:catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
Function:catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
Subcellular Location:Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .
Expression: Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,