Target：XE7

Gene Name：AKAP17A

Protein Name：A-kinase anchor protein 17A

Human Gene Id：8227

Human Swiss Prot No：Q02040

Immunogen：Synthesized peptide derived from XE7 . at AA range: 590-670

Specificity：XE7 Polyclonal Antibody detects endogenous levels of XE7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AKAP17A;CXYorf3;DXYS155E;SFRS17A;XE7;A-kinase anchor protein 17A;AKAP-17A;721P;B-lymphocyte antigen;Protein XE7;Protein kinase A-anchoring protein 17A;PRKA17A;Splicing factor; arginine/serine-rich 17A

Observed Band(KD)：80kD

Background：A-kinase anchoring protein 17A(AKAP17A) Homo sapiens This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010],

Function：caution:Was originally (PubMed:1438229) thought to be a cell surface protein involved in B-cell activation.,function:Splice factor regulating alternative splice site selection for certain mRNA precursors.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain.,tissue specificity:Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta.,

Subcellular Location：Nucleus speckle .

Expression：Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.