Target：TRH-R1

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：TRHR

Protein Name：Thyrotropin-releasing hormone receptor

Human Gene Id：7201

Human Swiss Prot No：P34981

Mouse Gene Id：22045

Mouse Swiss Prot No：P21761

Rat Gene Id：25570

Rat Swiss Prot No：Q01717

Immunogen：The antiserum was produced against synthesized peptide derived from human TRHR. AA range:195-244

Specificity：TRH-R1 Polyclonal Antibody detects endogenous levels of TRH-R1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TRHR;Thyrotropin-releasing hormone receptor;TRH-R;Thyroliberin receptor

Observed Band(KD)：50kD

Background： This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011],

Function：function:Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression： Brain,Pituitary,Placenta,