Target:TRFM
Gene Name:MFI2 MAP97
Protein Name:Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Human Gene Id:4241
Human Swiss Prot No:P08582
Mouse Swiss Prot No:Q9R0R1
Immunogen:Synthesized peptide derived from human protein . at AA range: 210-290
Specificity:TRFM Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):81kD
Background: The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008],
Function:function:Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,tissue specificity:Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.,
Subcellular Location:[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
Expression:Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.