Target：IL-2

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;PI3K-Akt signaling pathway;C-type lectin receptor signaling pathway;JAK-STAT signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Yersinia infection;Chagas disease;Measles;Human T-cell leukemia virus 1 infection;Coronavirus disease - COVID-19;Pathways in cancer;Autoimmune thyroid disease;Inflammatory bowel disease;Allograft rejection;Graft-versus-host disease

Gene Name：IL2

Protein Name：Interleukin-2

Human Gene Id：3558

Human Swiss Prot No：P60568

Mouse Swiss Prot No：P04351

Rat Gene Id：116562

Rat Swiss Prot No：P17108

Immunogen：The antiserum was produced against synthesized peptide derived from human IL-2. AA range:16-65

Specificity：IL-2 Polyclonal Antibody detects endogenous levels of IL-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL2;Interleukin-2;IL-2;T-cell growth factor;TCGF;Aldesleukin

Observed Band(KD)：15kD

Background： The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],

Function：disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,

Subcellular Location：Secreted.

Expression： Blood,PCR rescued clones,Placenta,Spleen,