Target：IL18

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Legionellosis;Yersinia infection;African trypanosomiasis;Malaria;Tuberculosis;Influenza A;Inflammatory bowel disease;Rheumatoid arthritis;Lipid and atherosclerosis

Gene Name：IL18 IGIF IL1F4

Protein Name：Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

Human Gene Id：3606

Human Swiss Prot No：Q14116

Mouse Swiss Prot No：P70380

Rat Swiss Prot No：P97636

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：IL18 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：21kD

Background： The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011],

Function：function:Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,

Subcellular Location：Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .

Expression： Liver,Peripheral blood,Urinary bladder,