Target：IL-17Rα
Fields：Cytokine-cytokine receptor interaction;IL-17 signaling pathway;Alcoholic liver disease
Gene Name：IL17RA
Protein Name：Interleukin-17 receptor A
Human Gene Id：23765
Human Swiss Prot No：Q96F46
Mouse Gene Id：16172
Mouse Swiss Prot No：Q60943
Immunogen：The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190
Specificity：IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IL17RA;IL17R;Interleukin-17 receptor A;IL-17 receptor A;IL-17RA;CDw217;CD antigen CD217
Observed Band(KD)：90kD
Background： Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],
Function：function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,
Subcellular Location：[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Expression：Widely expressed.
