Target：GM2/GD2 synthase

Fields：Sphingolipid metabolism;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways

Gene Name：B4GALNT1

Protein Name：Beta-1,4 N-acetylgalactosaminyltransferase 1

Human Gene Id：2583

Human Swiss Prot No：Q00973

Mouse Gene Id：14421

Mouse Swiss Prot No：Q09200

Rat Gene Id：64828

Rat Swiss Prot No：Q10468

Immunogen：The antiserum was produced against synthesized peptide derived from human B4GALNT1. AA range:281-330

Specificity：GM2/GD2 synthase Polyclonal Antibody detects endogenous levels of GM2/GD2 synthase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：B4GALNT1;GALGT;SIAT2;Beta-1;4 N-acetylgalactosaminyltransferase 1;(N-acetylneuraminyl)-galactosylglucosylceramide;GM2/GD2 synthase;GalNAc-T

Observed Band(KD)：60kD

Background：beta-1,4-N-acetyl-galactosaminyltransferase 1(B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013],

Function：catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide = UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide.,function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Golgi apparatus membrane ; Single-pass type II membrane protein .

Expression： Brain,