Target：REL1

Fields：Neuroactive ligand-receptor interaction;Relaxin signaling pathway

Gene Name：RLN1

Protein Name：Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

Human Gene Id：6013

Human Swiss Prot No：P04808

Mouse Swiss Prot No：P47932

Rat Swiss Prot No：P01347

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：REL1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：20kD

Background：relaxin 1(RLN1) Homo sapiens Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013],

Function：function:Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.,similarity:Belongs to the insulin family.,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds.,tissue specificity:Prostate. Not expressed in placenta, decidua or ovary.,

Subcellular Location：Secreted.

Expression：Prostate. Not expressed in placenta, decidua or ovary.