Target：SRp40

Fields：Spliceosome;Herpes simplex virus 1 infection

Gene Name：SRSF5

Protein Name：Serine/arginine-rich splicing factor 5

Human Gene Id：6430

Human Swiss Prot No：Q13243

Mouse Gene Id：20384

Mouse Swiss Prot No：O35326

Rat Gene Id：29667

Rat Swiss Prot No：Q09167

Immunogen：The antiserum was produced against synthesized peptide derived from human SFRS5. AA range:71-120

Specificity：SRp40 Polyclonal Antibody detects endogenous levels of SRp40 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SRSF5;HRS;SFRS5;SRP40;Serine/arginine-rich splicing factor 5;Delayed-early protein HRS;Pre-mRNA-splicing factor SRP40;Splicing factor; arginine/serine-rich 5

Molecular Weight(Da)：31kD

Background： The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Function：function:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.,

Subcellular Location：Nucleus.

Expression： Brain,Colon,Epithelium,Fetal brain,Human endometrium carcin